Effectiveness of the modified scheme for treatment of Н.pylori-associated peptic ulcer of the duodenum in children

Background. None of the known regimens for treatment H.pylori-associated peptic ulcer duodenum (PUD) is 100 % effective. The purpose was to evaluate effectiveness modified comprehensive therapy Н.pylori-associated in children. Materials and methods. study included 66 patients aged 7 18 years with PUD acute stage. Serum vitamin D levels were measured using electrochemiluminescence method (Roche Diagnostics GmbH, Mannheim, Germany). classical stool culture used. children divided into three groups: first — 20 who received protocol eradication therapy, second 23 inclusion D3, third D3 a synbiotic. Results. average length stay hospital reduced by 18.8 %, those synbiotic additionally 23.8 compared group. During endoscopic examination conducted after 1 month, presence an elongated red scar at site defect observed significantly more often group I (65.5 %) than groups II (47.8 III (39.1 %), χ2 = 3.87, p < 0.05; year, 33.3 I, 17.3 II, 8.7 (p 0.01) had recurrence disease. determination main indicators scheme showed that relative risk disease will decrease 0.42 times (χ2 3.96, 0.05) when preparation 0.52 4.06, Conclusions. 1. Children have deficiency various disturbances intestinal microbiota, which can complicate course, increase chronicity process, reduce anti-Helicobacter therapy. 2. use duodenal associated H.pylori leads reduction duration clinical manifestations disease, inpatient sick frequency